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PROGRAM COMPONENTS The HIV AIDS program of Dow South Africa will provide access to: Information and education; A variety of prevention strategies, e.g. condoms Health services for the appropriate management of HIV related infections diseases, risk behavior and other diseases that may impact on the HIV AIDS epidemic or HIV AIDS individuals; Universal precautions including personal protective equipment for staff that may potentially be exposed to blood or blood products; Appropriate support and counseling services to employees affected by the disease and where reasonably possible to their families. LA9 Average hours of training per year per employee The average hours of training per employee was 11 hours in 2005. The use of web-based learning tools and dedicated Intranet training site Learn Dow.now continue to increase training productivity. 2006 training information is not available at the time of this report. LA10 Description of equal opportunity programs At Dow, we recognize value and leverage our differences for competitive advantage. It is a key to our success. We encourage a culture of mutual respect in which everyone understands and values the similarities and differences among our employees, customers, communities and other stakeholders. We work to provide an atmosphere that encourages positive interaction and creativity among all employees. Dow attracts and hires talented and motivated people who wish to excel. We provide equal access to the best jobs in the world for people who are willing to compete, and equal employment opportunity to all employees regardless of age, race, color, national origin, sexual orientation, gender, disability or religion. 1995 ; . There are only limited studies reporting the effects of metformin on IVF outcomes Stadtmauer et al., 2001; Onalan, 2005 ; . In the current study we demonstrated decreased levels of sFasL in follicular fluid and increased levels of sFas in serum samples among PCOS patients receiving metformin compared to those receiving placebo. Patients with PCOS on placebo had luteinized granulosa cell DNA fragmentation in follicular fluid samples. Similar DNA fragmentation was not observed in PCOS patients on metformin therapy, which may imply an antiapoptotic effect of metformin on soluble factors both in follicular fluid and serum. This effect can be a result of reduced androgen production by metformin that may inhibit apoptosis; however, the role of androgens in follicle development, whether atretogenic or trophic, is debatable probably due to interspecies differences in ovarian follicular development with different experimental conditions Jonard and Dewailly, 2004 ; . As in the b-cell in the pancreas Kefas et al., 2004 ; , metformin can also inhibit apoptosis in granulosa cells, which may result in the induction of biosynthesis and release pathways preventing the functional exhaustion. There was a tendency for higher number of retrieved oocytes, increased implantation and clinical pregnancy rates among PCOS patients on metformin; however, the differences were not statistically significant in comparison to those of PCOS patients on placebo in the current study. Apoptosis is suggested to predominate in the granulosa cell layer of preantral and antral follicles rather than the dominant follicles $ 10 mm ; in normal ovaries with androgen-dominant follicles uniformly displaying characteristics of apoptosis Yuan and Giudice, 1997 ; . The Fas FasL system may play a role in preventing oocyte atresia during folliculogenesis. Since levels of sFas and FasL may not be critical in controlling the quality of oocytes once they overcome meiotic arrest Page 4 of 5.