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DROUHET, E. and Committee Eds ; Proceedings of the 5th Congress of the International Society for Human and Animal Mycology, Paris, 1971. DRUCE, G.C. Hayward's botanist's pocket book. Revised Ed.19, 1930. DUDDINGTON, C.L. The friendly fungi. A new approach to the eelworm problem, 1957. DUDDINGTON, C L. The predacious fungi: Zoopagales and Moniliales, 1953. ex Biol. Rev. ; DUFRENOY, M.J. Dprissement des arbres fruitiers dans le Massif Central, 1927. DUGGAR, B M. Fungous diseases of plants, 1909. DUNCAN, U K. A guide to the study of lichens, 1959. DUNCAN, U K. assisted by JAMES, P W. Introduction to British Lichens, 1970. DUNCAN, U K. Lichen illustrations, 1963. DURAN, R & FISCHER, G W. The Genus Tilletia, 1961. DURRIEU, G. Etude ecologique de quelques groupes de champignons parasites de plantes spontanes dans les Pyrnes, 1966. EGGINS, H. see International Biodeterioration & Biodegradation, Vol.48, July-Dec.01. EINHELLINGER, A. Die gattung Russula in Bayern. Bibliotheca Mycologica 112, 1987. ELLIS, J B & EVERHART, B M. The North American Phyllostictas, 1900. ELLIS, J W. The fungus flora of the Hundred of Wirral, 1915. ELLIS, M.B. Some species of Corynespora. Mycological Papers No.65, 1956. ELLIS, M.B. Some species of Deightoniella. Mycological Papers No.66, 1956. ELLIS, M.B. Haplobasidion, Lacellinopsis and Lacellina. Mycological Papers No.67, 1957. ELLIS, M.B. Some species of Teratosperma. Mycological Papers No.69, 1957. ELLIS, M.B. Clasterosporium and some allied Dematiaceae-Phragmosporae. Mycological Papers No.70, 1958 ELLIS, M.B. Clasterosporium and some allied Dematiaceae-Phragmosporae. II. Mycological Papers No.73, 1959. ELLIS, M.B. Dematiaceous Hyphomycetes. Mycological Papers No.76, 1960. ELLIS, M.B. Dematiaceous Hyphomycetes. II. Mycological Papers No.79, 1961. ELLIS, M.B. Dematiaceous Hyphomycetes. III. Mycological Papers No.82, 1961. ELLIS, M.B. Dematiaceous Hyphomycetes. IV. Mycological Papers No.87, 1963. ELLIS, M.B. Dematiaceous Hyphomycetes. V. Mycological Papers No.93, 1963. ELLIS, M.B. Dematiaceous Hyphomycetes. VI. Mycological Papers No.103, 1965. ELLIS, M.B. Dematiaceous Hyphomycetes. VII. Curvularia, Brachysporium, etc. Mycological Papers No.106, 1966. ELLIS, M.B. Dematiaceous Hyphomycetes. VIII. Periconiella, Trichodochium, etc. Mycological Papers No.111, 1967. ELLIS, M.B. Dematiaceous Hyphomycetes. IX. Spiropes and Pleurophragmium. Mycological Papers No.114, 1968. ELLIS, M.B. Dematiaceous Hyphomycetes. X. Mycological Papers No.125, 1971. ELLIS, M.B. Dematiacous Hyphomycetes. XI. Mycological Papers No.131, 1972. ELLIS, M B & ELLIS, J P. Microfungi on miscellaneous substrates. An identification handbook, 1988. New enlarged ed. 1998. ELLIS, M B. & ELLIS, J P. Fungi without gills, 1990. ELLIS, M B. & ELLIS, J P. Microfungi on Land Plants. An identification handbook, 1985 + New Enlarged ed. 1997. ELLIS, M B. Dematiaceous Hyphomycetes, 1971. ELLIS, M B. More Dematiaceous Hyphomycetes, 1976. ELLWOOD, D.C., HEDGER, J.N., LATHAM, M.J., LYNCH, J.M. & SLATER, J.H. eds ; Contemporary microbial ecology, 1980. EMMONS, C W, BINFORD, C H & UTZ, J P. Medical Mycology, 1963. ENGEL, HEINZ et al, Schmier- und Pilzrhrlinge s.l. in Europa. Die Gattung Boletellus; Boletinus; Phylloporus; Suillus; Xerocomus, 1996. ENGLER, A & PRANTL, K. Die natrlichen Pflanzenfamilien, Teil, I, Abt. 1. Myxomycetes, Phycomycetes, Ascomycetes ; , 1897: Abt. I Basidiomycetes, Fungi Imperfecti ; 1900: Abt. Lichens ; , 1906. 2 Aufl., Bd. 8, Lichenes Flechten ; , 1926, Bd. 6 Hemibasidiomycetes, Hymenomycetes ; , 1928. ENGLISH, J L. A manual for the preservation of the larger fungi Hymenomycetes ; in their natural condition, 1882. ENGLISH, M P. Medical Mycology. Studies in Biology no. 119, 1980. ENGLISH, M P. Mordecai Cubitt Cooke. Victorian Naturalist, Mycologist, Teacher & Eccentric, 1987. ENVIRONMENT AGENCY Biodiversity strategy and action plan for the Environment Agency Thames Region ; Version 1, 2000. ERGO, A.B. La Fusaroise Vasculaire de l'Elaeis guineensis JACQ., 1978.
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1. 2. 3. McEvoy GK, Ed. American Hospital Formulary Service, AHFS Drug Information. American Society of Health-System Pharmacists. Bethesda. 2004 Kastrup EK, Ed. Drug Facts and Comparisons. Facts and Comparisons. St. Louis. 2004. Abate BJ, Barriere SL. Antimicrobial Regimen Selection. In: Pharmacotherapy. A Pathophysiologic Approach, Fifth Edition. Dipiro JT, Talbert RL, Yee GC, et al. Eds. McGrawHill. New York. 2002. Pg. 1817-29. Gilbert DN, Moellering, RC, Sande MA. The Sanford Guide to Antimicrobial Therapy 34th Edition. Hyde Park, Vermont. 2004. Murray L, Senior Editor. Package inserts. In: Physicians' Desk Reference, PDR Edition 58, 2004. Thomson PDR. Montvale, NJ. 2004. Tatro, Ed. Drug Interaction Facts. Facts and Comparisons. St. Louis. 2004. Garrison GD, Sorum PC, Hior W, Miller MM. High-dose versus standard-dose amoxicillin for acute otitis media. Ann Pharmacother. 2004; 38 1 ; : 158-60. Kacmar J, Cheh E, Montagno A, Peipert JF. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol. 2001; 9 4 ; : 197-202. Edwards RK, Duff P. Single additional dose postpartum therapy for women with chorioamnionitis. Obstet Gynecol. 2003; 102 5 Pt 1 ; 957-61. Spinnato JA, Youkilis B, Cook VD, et al. Antibiotic prophylaxis at Cesarean delivery. J Matern Fetal Med. 2000; 9 6 ; : 348-50. Gentry CA, Rodvold KA, Novak RM, Hershow RC, Naderer OJ. Retrospective evaluation of therapies for Staphylococcus aureus endocarditis. Pharmacotherapy. 1997; 17 5 ; : 990-7. Stevens DL, Smith LG, Bruss JB, et al. Randomized comparison of linezolid PNU-100766 ; versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections. Antimicrob Agents Chemother. 2000; 44 12 ; : 3408-13. Heldman AW, Hartert TV, Ray SC, et al. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. J Med. 1996; 101 1 ; : 68-76. Bland ML, Vermillion ST, Soper DE. Late third-trimester treatment of rectovaginal group B streptococci with benzathine penicillin G. J Obstet Gynecol. 2000; 183 2 ; : 372-6. Hook EW, Martin DH, Stephens J, Smith BS, Smith K. A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. Sex Transm Dis. 2002; 29 8 ; : 486-90. Smith NH, Musher DM, Huang DB, et al. Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. Int J STD AIDS. 2004; 15 5 ; : 328-32. Curtin-Wirt C, Casey JR, Murray PC, et al. Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis. Clin Pediatr Phila ; . 2003; 42 3 ; : 21925. Lode H, Magyar P, Muir JF, et al. Once-daily oral gatifloxacin vs. three-times-daily co-amoxiclav in the treatment of patients with community-acquired pneumonia. ClinMicrobiol Infect. 2004; 10 6 ; : 512-20. Innes HE, Smith DB, O'Reilly SM, et al. Oral antibiotics with early hospital discharge compared with in-patient intravenous antibiotics for low-risk febrile neutropenia in patients with cancer: a prospective randomized controlled single centre study. Br J Cancer. 2003; 89 1 ; : 43-9. Luterman M, Tellier G, Lasko B, Leroy B. Efficacy and tolerability of telithromycin for 5 or 10 days vs. amoxicillin clavulanic acid for 10 days in acute maxillary sinusitis. Ear Nose Throat J. 2003; 82 8 ; : 576-80. File TM Jr., Jacobs MR, Poole MD, et al. Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxicillin clavulanate. Int J Antimicrob Agents. 2002; 20 4 ; : 235-47. Allewelt M, Schuler P, Bolcskei PL, Mauch H, Lode H, Study Group on Aspiration Pneumonia. Ampicillin + sulbactam vs. clindamycin cephalosporin for the treatment of aspiration pneumonia and primary lung abscess. Clin Microbiol Infect. 2004; 10 2 ; : 163-70.
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Vancomycin, teicoplanin and linezolid are antibiotics used in the treatment of infections with MRSA, enterococci and multiresistant coagulase-negative staphylococci. The use of these substances in hospital care has increased during the last six years Figure 3.1.15.
Testoni, P.A., Lella, F., Bagnolo, F., Buizza, M. and Colombo, E. 1994 ; Controlled trial of different dosages of octreotide in the prevention of hyperamylasemia induced by endoscopic papillosphincterotomy. Ital. J. Gastroenterol., 26: 431-436. Tulassay, Z. and Papp, J. 1991 ; The effect of long-acting somatostatin analogue on enzyme changes after endoscopic pancrea-tography. Gastrointest. Endosc., 37: 48-50. Usadel, K.H., Kessler, H., Rohr, G., Kusterer, K., Palitzsch, K.D. and Schwedes, U. 1986 ; Cytoprotective properties of somatostatins. Klin Wochenschr, 64 suppl 7 ; : 59-63. Van Ooijen, B., Tinga, C.J., Kort, W.J., Zijlstra, F.J., Lamberts, S.W.J. and Wilson, J.H.P. 1992 ; Effects of long-acting somatostatin analog SMS 201-995 ; on eicosanoid synthesis and survival in rats with acute necrotizing pancreatitis. Dig. Dis. Sci., 37: 1434-1440. Zhu, Z.H., Holt, S., El-Lbishi, M.S., Grady, T., Taylor, T.V. and Powers, R.E. 1991 ; A somatostatin analogue is protective against retrograde bile salt-induced pancreatitis in the rat. Pancreas, 6: 609-613.
Table 1. Susceptibility of 540 isolates of S. pyogenes to 16 antibiotics MIC mg L ; Antimicrobial agent Erythromycin Clarithromycin Azithromycin Josamycin Clindamycin Penicillin Amoxicillin Cefaclor Cefuroxime Cefpodoxime Ceftriaxone Linezolid Ciprofloxacin Levofloxacin Tetracycline Vancomycin range 0.008 256 0.008 MIC50 0.06 0.25 MIC90 16 4 16 susceptible 86.7 86.5 86.7 Percentage of isolates intermediate 0 0.2 0 0 0.4 0 0 0 0.2 0 0 0 0.2 0 resistant 13.3 0 0 0 16.1 0.
Or ischemic n 5 ; dilated cardiomyopathy Table 1 ; . The inclusion criteria were: 1 ; echocardiographic evidence of LV ejection fraction 40% and LV internal diameter 58 mm; 2 ; clinical evidence of CHF despite conventional therapy; and 3 ; stable clinical conditions for the previous three months. Twelve patients were in New York Heart Association NYHA ; class II and four in NYHA class III. Exclusion criteria were myocardial infarction or treatment of coronary artery disease by interventional procedures for the previous six months, unstable angina, major arrhythmias Lown class IV ; , systemic hypertension, significant valvular heart disease, hypertrophic cardiomyopathy and chronic alcoholism. Eight patients were treated for three months with recombinant human GH at a dose of 4 IU given subcutaneously every other day, whereas eight patients received placebo, according to a randomized, double-blind design. Any other cardiovascular medication remained unchanged throughout the study period. Growth hormone and liothyronine.
From the Departments of Hematology Drs. Tardy-Poncet and Reynaud, Ms. Mazet, and Prof. Guyotat ; , Intensive Care Unit Drs. Tardy and Mahul ; , and Internal Medicine Dr. Mismetti ; , Hopital Nord CHRU, Saint-Etienne, France. Manuscript received December 23, 1997; revision accepted January 12, 1999. Correspondence to: Brigitte Tardy-Poncet, MD, Laboratoire d'Hemostase, Hopital Nord, CHRU Saint-Etienne, 42055 France.
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Community-acquired pneumonia CAP ; is a leading cause of hospitalization and may occur in previously healthy individuals without predisposing risk factors or in individuals with co-morbidities.2325 S. pneumoniae is the most frequent pathogen, particularly among those patients with concurrent bacteraemic pneumonia.23, 2529 Penicillin-based regimens have been the mainstays of treatment for more than 30 years, but increasing antibiotic resistance to penicillins, extendedspectrum cephalosporins, macrolides and fluoroquinolones threatens the future utility of these agents.3033 In a multinational, randomized, open-label Phase III study, 747 adult patients hospitalized with suspected communityacquired pneumonia received either linezolid 600 mg iv twice daily ; or ceftriaxone 1 g iv twice daily ; followed by a switch to oral therapy linezolid 600 mg twice daily or cefpodoxime 200 mg twice daily ; at the physician's discretion.16, 34 Of these patients, 534 were CE follow-up assessment 1521 days after the end of treatment ; and 185 were ME. The treat and lomefloxacin.
Treatment of Gram-positive bacterial infections is currently a therapeutic challenge because many of these pathogens are now resistant to standard antimicrobial agents. The emergence of multidrug-resistant, Gram-positive pathogens emphasizes the need for new antimicrobial therapy. Linezolid is an oxazolidinone antibiotic with a novel mechanism of action that works by inhibiting bacterial protein synthesis by blocking formation of the initiation complex. It is active against Gram-positive organisms resistant to other antibiotics, including methicillin-resistant Staphylococcus aureus MRSA ; , penicillin-resistant Streptococcus pneumoniae and vancomycin-resistant enterococci VRE ; . Results are encouraging from several large-scale, randomized, Phase III trials comparing the efficacy and safety of linezolid with standard comparator agents for the treatment of nosocomial pneumonia, community-acquired pneumonia, skin and skin structure infections, and infections due to MRSA and VRE. Intravenous oral linezolid is a promising antimicrobial agent and provides the clinician with an additional treatment option, particularly among the limited therapies for resistant Gram-positive bacterial infections!
We thank edgar hoffmann, technician at the center for medical research, department of anesthesiology and intensive care medicine, tubingen university hospital, for the measurement of linezolid levels in serum and cerebrospinal fluid and lomotil
J. Yoshida-Matsuoka, N.J.P Ryba1 and R.M. Costanzo . Department of Physiology, Virginia Commonwealth University, MCV Campus, PO Box 980551, Richmond, VA 23298-0551 and 1Taste and Smell Unit, NIDCR, National Institutes of Health, Bethesda, MD 20892, USA.
2558. Mr. B. Syamala Rao Chief Engineer Electrical ; Retd. Govt. of Orissa Door No.50-104-2 C, Plot No.12A T P T Colony, Seethammadhara Visakhapatnam-530013 2559. Mr. Bathula Prasada Rao Retd. District and Sessions Judge, Journist Colony, Mogalrajpuram, H.No. 32-13-53 2, Krishna District, Vijayawada-529910 2560. Mr. C Srinibasa Rao Chartered Engineer, Bank Valuer Balaji, No.9, Dwarka Colony Myalapore Chennai-600004 2561. Mr. C. Rama Rao Civil Engineer B-179, Lok Vihar, Pitampura Delhi-110034 2562. Mr. G.L. Rao Chief Engineer Retd. ; Plot No. 233, Road No.36, Jubilee Hills Hyderabad-500033 2563. Mr. G.S.K. Mohan Rao Executive Director Continental Shipping Corporation Limited 35, Hill Park, A G Bell, Marg Malabar Hill Mumbai-400006 2564. Mr. C.M. Rao Consulting Engineer `Rangalahari' 4-72-7, Lawsonsbay Colony Visakhapatnam-530017 2565. Mr. G.V.R. Krishna Rao Retd. Chief Engineer 1st Floor, Plot No.50, Gazetted Officer's Colony, Isukathota Visakhapatnam-530022 2566 and lomustine.
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N. ~ 1. Documents and other materials created or received by a commercial enterprise in the course of operations and preserved for future use. 2. LAW Documents and other materials held by an individual or organization that are not considered hearsay and admissible as evidence under the business exemption in rules of evidence. Notes An organization may have many business records1 that fall under the general definition of a record, 2 but which are not covered by the more specific definition of business records2 established by the Federal Rules of Evidence cited below; most states have similar rules ; . The distinction is significant in the context of litigation. All materials that fall under the more general understanding of business records are subject to discovery, but only those records that fall under the hearsay exemption of the Federal Rules of Evidence are admissible in court as evidence. Citations Records of regularly conducted activity. A memorandum, report, record, or data compilation, in any form, of acts, events, conditions, opinions, or diagnoses, made at or near the time by, or from information transmitted by, a person with knowledge, if kept in the course of a regularly conducted business activity, and if it was the regular practice of that business activity to make the memorandum, report, record or data compilation, all as shown by the testimony of the custodian or other qualified witness, or by certification that complies with Rule 902 11 ; , Rule 902 12 ; , or a statute permitting certification, unless the source of information or the method or circumstances of preparation indicate lack of trustworthiness. The term business as used in this paragraph includes business, institution, association, profession, occupation, and.
The ratio of the amount of CO2C released after 3 d over the amount released after 28 d was positively related to the soluble C content of the ORs up to about 50% proportional C release Fig. 6 ; . Lignin, polyphenol, and soluble C content of the ORs explained 86% of the variation in cumulative C mineralization Table 3 ; . In vitro dry matter digestibility was related to lignin, polyphenol, and soluble C content, explaining 83% of its variation. Cumulative N mineralization was related to N, C, lignin, and soluble C content of the ORs, although N content on its own explained already 76% of the variation Table 3 ; . When considering only Class C data Fig. 4 ; , a highly significant linear relationship was observed between N-immobilization and the N content of the ORs Fig. 7a ; . For Class A data Fig. 4 ; , no significant relationship between N mineralization and any specific OR quality parameter was observed. Excluding the Gliricidia samples, however, N mineralization was linearly related with the lignin N ratio of the ORs Fig. 7b ; . Note that for Class A ORs, no and lortab.
WEBELOS RESIDENT T-SHIRT ORDER FORM This year each scout and leader will get one T-shirt for staying the week at camp. We will be placing the order before camp starts. It is important that you get the reservation forms in and the T-shirt order forms in by May 1, 2007. Additional Shirts may be ordered for .00 each. Please mark which week your Scout will be at camp. Week 1 Week 2 Week 3.
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Contraction. Once the heart has reached its capacity to dilate in order to compensate, then a resistance to diastolic filling takes place. This results in an increased left ventricular end diastolic pressure LVEDP ; , which is transmitted to the pulmonary capillaries and causes pulmonary congestion. Preload is the diastolic muscle length of the myocardial fibers; it is closely approximated by the pulmonary capillary wedge pressure PCWP ; in the left ventricle and central venous pressure CVP ; in the right ventricle. Venous return, total blood volume, and atrial structure affect the preload. In heart failure, there is an increase in preload as a result of the compensatory mechanism of the kidneys. Afterload is the force or resistance against which the ventricles must contract, or systemic vascular resistance SVR ; . This is generally reflected as the arterial BP. Forms of Heart Failure Differentiating the forms of heart failure is generally done by describing the pathophysiological state. Clinically, the APN must differentiate the form of heart failure that the patient has, as the treatment is significantly different for each form. Chronic heart failure generally takes place after years of the heart attempting to compensate for the underlying cardiac disorder. If the progression of the underlying cardiac condition develops slowly, compensatory mechanisms are initiated and the patient has time to adjust to the gradual decrease in CO. Conditions that lead to chronic heart failure might be cardiomyopathy or valvular heart disease; however, if there is a sudden event such as MI that interferes with the normal cardiac compensatory mechanisms, acute heart failure becomes evident. Acute heart failure generally presents as acute pulmonary edema. Another differentiation is made based on the cardiac output. Low-output failure generally occurs in and linezolid.
Operatively, but the implanted S-KPro was well positioned, without retinal detachment. Another S-KPro was partially extruded suddenly at 9 weeks; the probable cause of the extrusion was incidental trauma, probably caused by scratching. All S-KPros were well tolerated, and transplanted AMs were translucent at 1 week. Few inflammatory cells were shown in a chamber behind all of the S-KPros. At 2 or 3 weeks, the most prominent change was the appearance of neovascularization, which started from the limbus and grew toward the center. At this time, the was partially dissolved and the fundus red reflex was normal. Retinoscopic refraction showed hyperopia of about 10 diopters D ; . At weeks, peripheral retinal detachment was observed in most cases, but the S-KPros and lovenox.
Linezolid against five unusual Gram-positive pathogens. Our data further support the potential clinical application of daptomycin against infections caused by Leuconostoc and Pediococcus species, though only limited clinical data has been reported 11 ; . Infection caused by L. monocytogenes is rare in.
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13. Street JS, Clark WS, Gannon KS, et al: Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group. Arch Gen Psychiatry 2000; 57: 968976 Pollock BG, Mulsant BH, Sweet RA, et al: An open pilot study of citalopram for behavioral disturbances of dementia: plasma levels and real-time observations. J Geriatr Psychiatry 1997; 5: 7078 Parsa MA, Greenaway HE, Bastani B: Quetiapine for the treatment of psychosis in Lewy body disease. Neurology 2000; 54 suppl 3 ; : A451A452 16. Katz IR, Jeste DV, Mintzer JE, et al: Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. J Clin Psychiatry 1999; 60: 107115 Jeste DV, Okamoto A, Napolitano J, et al: Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. J Psychiatry 2000; 157: 11501155 Lyketsos CG, Sheppard J-ME, Steele CD, et al: Randomized, placebo-controlled, double-blind clinical trial of sertraline in the treatment of depression complicating Alzheimer disease: initial results from the Depression in Alzheimer's Disease Study. J Psychiatry 2000; 157: 16861689 Houlihan DJ, Mulsant BH, Sweet RA, et al: A naturalistic study of trazodone in the treatment of behavioral complications of dementia. J Geriatr Psychiatry 1994; 2: 7885 McKhann G, Drachman DA, Folstein MF, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984; 34: 939944 Lopez OL, Becker JT, Klunk W, et al: Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades, I. Neurology 2000; 55: 18541862 Mezzich JE, Dow JT, Cottman GA: Developing an information system for a comprehensive psychiatric institute, I: principles and lumigan.
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Minutes and then permeabilized with 0.5% v v NP-40 solution for 30 minutes, after which cells were stained at room temperature. Cells were incubated with unconjugated antibodies against viral antigens for 30 minutes, followed by an additional 30 minutes' incubation with fluorochrome-conjugated Abs. Propidium iodide was sometimes used for nuclear counterstaining on cytospins and lunesta.
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