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CONCLUSIONS: The Onplant and Orthosystem provided stable anchorage during the alignment phase, and the headgear even moved the molars distally. However, the transpalatal bar resulted in insufficient anchorage during the alignment phase. 20 COMPARISON OF THE INITIAL FORCE SYSTEMS PRODUCED BY DIFFERENT LEVELLING ARCHWIRES L Fuck, D Drescher, Department of Orthodontics, Heinrich-Heine-University Dsseldorf, Germany AIM: Orthodontic treatment with straightwire appliances usually begins with the insertion of a fully ligated levelling archwire. In contrast to a segmented approach, the force systems found in multi-tooth geometry are indeterminate and difficult to predict. Since many patients report pain during the initial phase of orthodontic therapy, it is assumed that the magnitude of the applied force systems must be high. The purpose of this study was thus to determine and compare the forces and moments produced by 50 levelling archwires in dental arches with different degrees of crowding. MATERIALS AND METHOD: From 250 patients, three maxillary and three mandibular casts representing mild, moderate and severe crowding were selected. Each cast was fitted with brackets and the initial force systems produced by 50 levelling archwires were measured using a three-dimensional force moment sensor. An ambient temperature of 37C was established to measure the forces and moments on all incisors, canines and premolars. RESULTS: The force systems generated by most archwires were found to exceed the force magnitudes recommended in the literature, particularly for extrusive and intrusive tooth movements. Only six archwires delivered vertical forces constantly lower than 1 N, which, however, did not correlate with the degree of crowding. Only superelastic NiTi archwires with a very small diameter, as well as certain multi-stranded archwires, produced force systems that could be considered physiological. CONCLUSIONS: Archwires with small diameters and low stiffness, such as most multi-stranded and superelastic archwires, are believed to deliver comparatively light force systems. The findings of this study demonstrate that the actual measured force systems produced by most archwires cannot be considered adequate and are likely to cause damage such as root resorption. 21 LONG-TERM CHANGES OF UPPER LIP POSITION RELATIVE TO THE INCISAL EDGE P Fudalej, National Research Institute of Mother and Child, Centre for Craniofacial Disorders, Warsaw, Poland AIM: To establish the long-term change in upper lip position relative to the incisal edge from 16 to 44 years of age. MATERIALS AND METHOD: The records of 36 females and 18 males were selected from the Post-Retention Study, University of Washington, based on the following criteria: good quality cephalograms taken post-treatment T2; mean age 16.3 years ; , at least 10 years post-retention T3; mean age 31.5 years ; , and at least 20 years post-retention T4; mean age 44.4 years ; . Linear measurements: anterior and posterior face heights, nasion-incision superius, nasion-apex superius, nasion-stomion superius and the angular measurements: inclination of mandibular plane, inclination of upper and lower incisors and interincisal angle were measured on each cephalogram. The position of the upper lip relative to the incisal edge was calculated by subtracting nasion-stomion superius distance from nasion-incision superius distance. To test the change in each measurement and the differences between males and females, t-tests were carried out. RESULTS: From T2 to T3, anterior and posterior face heights increased resulting in anterior rotation of the mandible in both males and females. The changes in the male group were more pronounced. From T2 to T3, the stomion superiusincision superius distance decreased by 1.3 mm in males and by 0.3 mm in females. From T3 to T4, craniofacial growth was limited and similar in both genders. Stomion superius-incision superius distance decreased by 1.3 mm in males and females. CONCLUSIONS: The upper lip elongates from the age of 16 to years in both genders. From T2 to T3 the elongation of the upper lip is compensated by eruption of the maxillary incisors, but only in females. From T3 to T4 minimal craniofacial growth does not compensate for lip elongation thus resulting in a decrease of stomion superius-incision superius distance in both genders. 22 EVOLUTION AND AGEING OF MAN AND INDIVIDUAL VARIATION: CAN WE DELAY AGEING? R Gasser, Department of Cariology, University of Graz, Austria KEYNOTE ADEDRESS The question as to whether we can delay ageing has been raised since the beginning of time and answers have always conflicted with reality. Modern medicine has failed to prevent ageing, but can we delay ageing? Currently the process of ageing can neither be stopped nor delayed by any drug available, tested in large study populations with clear knowledge e157.
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The use of PGA and OLA scores instead of PASI scores may complicate marketing. It may be a ~22% little confusing when it comes to comparing the therapies, but sources do not believe it will be a problem with the FDA. One expert commented, "People like to compare PASI scores, but you can't really do that because there are no head-to-head trials. But marketing will be a little difficult, and there will be some confusion. But the measurements used are the way dermatologists practice." A New York doctor said, "OLA is not an issue. We've been dealing with retinoids for a long time. I need to see on my own how it works.I would rather use an oral if I can." Another doctor said, "The number of patients studied with oral tazarotene is an issue, but, on the other hand, PASI is suspect. The proof will be in the pudding. Not having to get prior authorization for oral tazarotene will help. Most of the time Enbrel is approved, but so far, I haven't gotten any approvals for Amevive or Raptiva." A Texas doctor added, "If oral tazarotene is priced right and if no prior authorization is needed, it will win." Doctors said they generally try not to keep patients on oral retinoids for too long, and most said they rotate treatment after a year. Sources could not estimate yet how long they will leave patients on oral tazarotene. A Minnesota doctor said, "This is not a life-time drug. It is very drying, so I taper use after three months to a couple of years." A Texas dermatologist said, "Oral tazarotene could be a long-term therapy like Accutane, which is supposed to be used for five months, but is really used much longer." A speaker commented, "Oral tazarotene tends to peak in efficacy at 1620 weeks does seem to have milder cutaneous effects and less impact on triglycerides, but there was a minor impact on bone. I don't think we would keep a patient on this continuously for a year." Another expert said patients who achieve results may remain on oral tazarotene drug long-term, "You don't need to stop it when the patient clears. You keep it going to avoid flares." There was no information available at the AAD meeting on how Allergan intends to price oral tazarotene, but cost definitely will affect adoption, dermatologists agreed. Academic experts predicted that dermatologists would switch rapidly almost "instantaneously" and completely from Soriatane to oral tazarotene when it is approved. They predicted that oral tazarotene would have larger sales than Soriatane because it would be used widely in combination with other agents, including biologics and UVB. One expert said, "Dermatologists know retinoids. They are very confident with them, and I think we will switch. It looks like Roche is exiting the market. It's withdrawn its sales force. Some patients may not want to switch, but Tazorac will have the lion's share.I see the possibility of adding Tazorac or it having a cost-sparing effect on biologics ; rmatologists and telithromycin.
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IVF outcome with highly purified hMG and recombinant FSH Westergaard LG, Erb K, Laursen SB, Rex S and Rasmussen PE 2001 ; Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotrophic women down-regulated with a gonadotropinreleasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study. Fertil Steril 76, 543549. Weston AM, Zelinski-Wooten MB, Hutchinson JS, Stouffer RL and Wolf DP 1996 ; Developmental potential of embryos produced by in-vitro fertilization from gonadotrophin-releasing hormone antagonist-treated macaques stimulated with recombinant human follicle stimulating hormone alone or in combination with luteinising hormone. Hum Reprod 11, 608613. Wolfenson C, Groisman J, Couto AS, Hedenfalk M, Cortvrindt RG, Smitz JEJ and Jespersen S 2005 ; Batch-to-batch consistency of human-derived gonadotrophin preparations compared with recombinant preparations. Reprod Biomed Online 10, 442454. Submitted on April 26, 2006; resubmitted on June 8, 2006; accepted on June 23, 2006 and teniposide.
Samuel Scheidt, Franz Tunder, Dietrich Buxtehude, Johann Sebastian Bach, Johann Heinrich Schein, John Jenkins, William Byrd, Tobias Hume, William Lawes, John Dowland; Joe Duddell, Uro Rojko prva izvedba novega dela first performance of a new work Izvrstni ansambel viol da gamba Concordia `e ve~ kot desetletje navdu uje ob~instvo z intenzivno igrivim, virtuoznim in izraznim muziciranjem. Njihov koncertni spored o ljubezni in smrti predstavlja ljubezenske in verske instrumentalne skladbe in pesmi ter `alostinke, ki so nastale v senci verskih vojn 17. stoletja. Ansambel je tudi eden pobudnikov novih skladb za zgodovinska glasbila tokrat bo prvi~ izvedel novo delo skladatelja Uro a Rojka. Na koncertu se bo instrumentalistom pridru`ila sopranistka Julia Gooding, ki jo odlikujeta barvit, zvo~no bogat glas in izreden glasbeni ob~utek. The superb viol consort Concordia has enchanted audiences for more than a decade with the intensity, joyfulness, virtuosity and expression of its music-making. The ensemble's concert programme is dedicated to the theme of Love and Death, presenting songs of love, faith and lamentation, written under the shadow of the religious wars of the 17th century. Concordia, well-known for commissioning new works for historical instruments, will be doing a premier performance of a new piece by the Slovene composer Uro Rojko. For this concert the consort will be joined by the soprano Julia Gooding, whose voice is distinguished by a rich, colourful timbre and musical sensitivity.
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