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Ben, Yuxing with Chang, Hsueh-Chia ; Nonlinear Smoluchowski slip velocity and micro-vortex generation. English summary ; J. Fluid Mech. 461 2002 ; , 229238. Summary ; 2003f: 82107 82D99 ; Bena, Ioana with Van den Broeck, Christian; Kawai, Ryoichi; Copelli, Mauro; Lindenberg, Katja ; Collective behavior of parametric oscillators. English summary ; Phys. Rev. E 3 ; 65 2002 ; , no. 3, 036611, 18 pp. Summary ; 2003c: 82044 82C05 ; with Saxena, Avadh; Sancho, Jos M. ; Interaction of a discrete breather with a e lattice junction. English summary ; Phys. Rev. E 3 ; 66 2002 ; , no. 3, 036617, 13 pp. Summary ; 2003h: 37137 37K60 ; Bena, Iosif with Vaman, Diana ; The polarization of M5-branes and little string theories with reduced supersymmetry. English summary ; J. High Energy Phys. 2001, no. 11, Paper 32, 26 pp. Angel Maria Uranga ; 2003h: 81158 81T30 ; with Nastase, Horatiu; Vaman, Diana ; Propagators for p-forms in AdS 2p + 1 and correlation functions in the AdS 7 2, 0 ; CFT correspondence. English summary ; Phys. Rev. D 3 ; 64 2001 ; , no. 10, 106009, 13 pp. Summary ; 2003a: 83071 83E15.
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BLOOD PRODUCTS AND PLASMA SUBSTITUTES. 9 CARDIOVASCULAR DRUGS. 9 DERMATOLOGICAL DRUGS . 11 DIURETICS . 12 GASTROINTESTINAL DRUGS . 12 HORMONES, OTHER ENDOCRINE DRUGS AND CONTRACEPTIVES. 13 IMMUNOLOGICALS . 14 15.1 15.2 Diagnostics. 14 Sera and Immunologicals. 15 Vaccines for Universal Immunization. 15 Vaccines for Specific Use . 15 Immunosuppressants . 16.
TABLE 1. Prevalence of prelnfarction characteristic * and hospital course in 1, 120 women and 3, 688 men surviving hospttaJIzation for acute myocardial infarction, Israel, July 1981 to October 1994.
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Clearly marked and instructions for specific operations are provided for on many of the screens. The panel verbiage is available in eight languages as standard and can be changed on the fly without having to turn off the chiller. Data can be displayed in either English or Metric units plus keypad entry of setpoints to 0.1 increments. Security access is provided to prevent unauthorized changes of setpoints. This is accomplished with three different levels of access and passwords for each level. There are certain screens, displayed values, programmable setpoints and manual controls not shown that are for servicing the chiller. They are only displayed when logged in at service access level. Included in this is the Advanced Diagnostics and troubleshooting information for the chiller and the panel. The panel is fused through a 1-1 2 or 2 KVA transformer in the compressor motor starter to provide individual over-current protected power for all controls. Numbered terminal strips for wiring such as Remote Start Stop, Flow Switches, Chilled Water Pump and Local or Remote Cycling devices are provided. The Panel also provides field interlocks that indicate the chiller status. These contacts include a Remote Mode Ready-to-Start, a Cycling Shutdown, a Safety Shutdown and a chiller Run contact. Pressure transducers sense system pressures and thermistors sense system temperatures. The output of each transducer is a DC voltage that is analogous to the pressure input. The output of each thermistor is a DC voltage that is analogous to the temperature it is sensing. Setpoints can be changed from a remote location via 010VDC, 4-20mA, contact closures or through serial communications. The adjustable remote reset range [up to 20F 11.1C ; ] provides flexible, efficient use of remote signal 5.
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Provider Types Affected Provider types affected include organization health care providers and suppliers who are covered entities under the Health Insurance Portability and Accountability Act of 1996 HIPAA ; and who are enrolled in the Medicare program. These are certified providers and suppliers, supplier groups and supplier organizations, and suppliers of durable medical equipment, prosthetics, orthotics, and supplies DMEPOS ; . This information does not apply to health care providers who are enrolled in Medicare as individual practitioners, such as physicians and nurse practitioners, nor does it apply to sole proprietors. ; Key Points Medicare is transitioning from the provider identifiers it currently uses in HIPAA standard transactions to the new National Provider Identifier, or NPI. For Medicare organization health care providers, the current identifiers could include: Online Survey Certification and Reporting OSCAR ; system numbers; National Supplier Clearinghouse NSC ; numbers; Provider Identification Numbers PIN and Unique Physician Identification Numbers UPIN ; used by Medicare. These numbers are now considered legacy identifiers or legacy numbers. Medicare is transitioning from these legacy identifiers to National Provider Identifiers, or NPIs. Note: When applying for an NPI, Medicare providers are urged to include their legacy numbers, particularly their Medicare legacy number, on the NPI application form. By regulation, Medicare organization health care providers who are HIPAA-covered.
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Advertising and promotion expenses increased 8% over the prior year to , 672 million in 2000, primarily as a result of a direct-to-consumer campaign for PRAVACHOL * and launch spending for GLUCOVANCE and TEQUIN * . In 1999, advertising and promotion expenses increased 2% from 1998 to , 549 million. As a percentage of sales, advertising and promotion expenses remained at prior year levels of 9.2% and decreased from 10.1% in 1998, reflecting an improvement in the effectiveness of the advertising and promotion spending. Marketing, selling and administrative expenses, as a percentage of sales, decreased to 21.2% in 2000 from 22.4% in 1999 and 24.5% in 1998. This decreasing trend is a result of slower rates of increase in marketing, sales force and general administrative expenses compared with revenue increases in the same period. The Company's investment in research and development totaled , 939 million in 2000, an increase of 10% over 1999, and to 10.6% in 2000, as a percentage of sales, compared with 10.4% in 1999 and 10.0% in 1998. This spending level reflects the Company's commitment to research over a broad range of therapeutic areas and to clinical development of new products. Over the past five years, research and development expenses have increased at a compound annual growth rate of 11%. In 2000, research and development spending dedicated to pharmaceutical products increased 14%, and was 13.0% of pharmaceutical sales compared with 12.6% and 12.4% in 1999 and 1998, respectively. As described in the notes to the financial statements, in the first quarter of 2000, the Company completed the sale of three pharmaceutical products - Estrace Cream, Ovcon 35 and Ovcon 50 as well as its Sea Breeze brand in Japan. In 1999, the Company acquired CAL-C-TOSE * , a leading nutritional milk modifier product in Mexico. Also, in 1999, the Company completed the sale of Laboratori Guieu, SpA, an Italian-based gynecological, pediatric and dermatological products business. In 1998, the Company acquired Dong-A Biotech Co., Ltd., a marketer and distributor of pharmaceutical products in South Korea. Also, in 1998, the Company divested its Ban brand of anti-perspirants and deodorants; A S GEA, a Denmark-based generic drug business; and Hexachimie, a specialty chemical manufacturer based in France. Discontinued Operations Clairol sales decreased 6% to , 894 million. Domestic sales decreased 4% while international sales decreased 9% 8% excluding foreign exchange ; . In 1999, Clairol sales increased 4% to , 020 million from , 940 million in 1998. Zimmer sales increased 9% to , 053 million, led by an increase in sales of knee joint replacements of 10% to 6 million, of hip replacements of 14% to 9 million and of fracture management products of 15% to 5 million. In 1999, Zimmer sales increased 5% to 3 million from 9 million in 1998. As described in the notes to the financial statements, in the third quarter of 2000, the Company completed the sale of Matrix Essentials, Inc. Matrix ; , an affiliate of Clairol. Matrix sales for the first six months of 2000 were 8 million and were 1 million for the full year in 1999. As described in Note 2 to the financial statements, in 2000 and 1998 the Company recorded restructuring charges to discontinued operations of million and million before taxes, respectively, primarily in connection with workforce reductions. In 2000, the Company recorded a pretax gain of 2 million 0 million after taxes ; on the sale of Matrix. The gain is included in the gain on disposal of discontinued operations. As a result of the restructuring charges, net earnings from discontinued operations were 5 million in 2000 and 1 million in 1998. Net earnings from discontinued operations, excluding the restructuring charges, increased 5% to 7 million in 2000 and decreased 10% to 8 million in 1999. 24.
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Domized, controlled, and blinded and must enroll sufficient numbers of patients to obtain valid statistical data on the efficacy of the drug and are the "pivotal" trials on which FDA approval is based Phosphorylation: addition of a phosphate to an organic compound, such as a protein, by specific enzymes phosphotransferases or kinases to change their functional status of proteins i.e., level of activation ; Proliferation: reproduction of cells; each cell divides by a process called mitosis into 2 daughter cells. Cellular proliferation is tightly regulated; loss of that regulation is the cause of cancer Reduced: having had an electron removed, usually accomplished by removing an oxygen or adding a hydrogen; see Appendix I, below S-glutathionylation: the addition of glutathione GSH ; to cysteine residues of proteins by disulfide links Stage III IV: See Appendix II Sustained virologic response: reduction of levels of the virus in blood below the level of detection for at least 6 months after continuation of therapy. Methods of testing have improved tremendously over the past decade and "level of detection" is very low, but it may not mean complete disappearance from blood, or some HCV may remain sequestered in the liver. For that reason, only patients who maintain negative blood levels for 6 months can be considered to be in remission and thiamin.
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Figure Legends Figure 1. Electron Micrograph of A Typical Myonucleus Panel A ; and a Muscle Satellite Cell Panel B ; Muscle satellite cells S ; were identified by their location inside the basal lamina, indicated by inverted triangles ; and outside the sarcolemma indicated by arrows ; , and an independent cytoplasm. In contrast, a myonucleus M ; is located inside the sarcolemma of the muscle fiber, and does not contain an independent cytoplasm. The bar is 1 m and thioguanine.
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Bristol-Myers's Mr. Skule says that the write-off was appropriate, and "to say otherwise is just not true." Meanwhile, the company, like many of its rivals, has had a tough time finding new drugs to replace those whose patents expire. Mr. Dolan, taking the top job in February 2001, promised to double both sales and earnings in five years -- his "mega-double" promise, he called it. Two products the now-46year-old CEO said would help meet this goal were Tequin, an antibiotic, and Vaniqa, to reduce facial hair in women. But Bristol-Myers sold Vaniqa last year, for just .5 million, and prescription demand for Tequin in the latest quarter was off 23%. Mr. Skule says Mr. Dolan no longer stands behind his "mega-double" promise. Since Bristol-Myers merged with Squibb in 1989, the combined company has spent billions on research but hasn't launched a single major drug discovered in-house. The scarcity of new drugs made planning a tenuous exercise, even as it added to pressure from the top. Two former executives say strategic planning became a somewhat-empty exercise because whatever plans they presented, top management would essentially tell them what their targets were going to be. Asked about this, Mr. Skule responded: "We do and will continue to have a strategic-planning process, and business heads do and must set targets, and the chairman and everyone else expects you to make those targets and terfenadine!
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